The reproductive system is a complex collection of organs with a very unique biology, and an endocrine system that links these organs together. At key life transitions, the organs of the reproductive system undergo tremendous change; notably during prenatal life, birth, at puberty as well as through the menopausal transition. Despite a healthy reproductive system being critical for overall health and well-being, we understand very little about the cell and molecular events involved in the formation and function of reproductive organs, the hormones that regulate them, and how aging, the environment, metabolism, stress and sleeplessness can affect them. Researchers in the Center are addressing these big questions through scientific discovery so as to promote reproductive health and reproductive longevity.